Standard Article

Domain Duplication and Gene Elongation

  1. Wen-Hsiung Li,
  2. Kateryna D Makova

Published Online: 15 JUL 2006

DOI: 10.1038/npg.els.0005097



How to Cite

Li, W.-H. and Makova, K. D. 2006. Domain Duplication and Gene Elongation. eLS. .

Author Information

  1. University of Chicago, Chicago, Illinois, USA

Publication History

  1. Published Online: 15 JUL 2006


A protein domain is a well-defined region within a protein that performs a specific function. Thus duplication of a protein domain may enhance the function of the protein. The fact that many extant proteins contain duplicated domains suggests that present-day complex proteins have evolved from simple proteins mainly via domain duplication.


  • protein domain;
  • duplication;
  • exons;
  • module;
  • new function