Standard Article

Nucleotide Substitution: Rate of

  1. Wen-Hsiung Li

Published Online: 15 JUL 2006

DOI: 10.1038/npg.els.0005109



How to Cite

Li, W.-H. 2006. Nucleotide Substitution: Rate of. eLS. .

Author Information

  1. University of Chicago, Chicago, Illinois, USA

Publication History

  1. Published Online: 15 JUL 2006


The rate of nucleotide substitution in a DNA sequence is defined as the number of nucleotide substitutions per site per unit time. It is a basic quantity in the study of DNA sequence evolution.


  • nucleotide substitution;
  • rate of evolution