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Selective and Structural Constraints

  1. Austin L Hughes

Published Online: 15 JUL 2006

DOI: 10.1038/npg.els.0005124



How to Cite

Hughes, A. L. 2006. Selective and Structural Constraints. eLS. .

Author Information

  1. University of South Carolina, South Carolina, USA

Publication History

  1. Published Online: 15 JUL 2006


The neutral theory of molecular evolution predicts that the rate of evolution will be low in portions of genes and of proteins that are functionally important. This insight is the basis for bioinformatics strategies that use sequence information to make functional predictions.


  • amino acid sequence evolution;
  • neutral theory;
  • purifying selection;
  • protein function;
  • synonymous and nonsynonymous substitution