Standard Article

Dopamine D4 Receptor (DRD4) Box Score

  1. Richard P Ebstein1,
  2. Avraham N Kluger2,
  3. Zahava Siegfried2

Published Online: 15 JUL 2006

DOI: 10.1038/npg.els.0005158



How to Cite

Ebstein, R. P., Kluger, A. N. and Siegfried, Z. 2006. Dopamine D4 Receptor (DRD4) Box Score. eLS. .

Author Information

  1. 1

    S. Herzog Hospital, Jerusalem, Israel

  2. 2

    The Hebrew University of Jerusalem, Jerusalem, Israel

Publication History

  1. Published Online: 15 JUL 2006


Only recently has a specific genetic variant been associated with a human personality trait, Novelty Seeking. Since the first report in 1996, a number of studies have sought to replicate these first findings. This article summarizes the current status of the association between the dopamine D4 receptor (DRD4) gene and Novelty Seeking based on a recent meta-analysis of almost four thousand subjects so far examined in molecular genetic studies.


  • personality;
  • genetics;
  • dopamine D4 receptor;
  • meta-analysis;
  • novelty Seeking