Standard Article

Multiple Alignment

  1. Julie Thompson,
  2. Olivier Poch

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005258



How to Cite

Thompson, J. and Poch, O. 2005. Multiple Alignment. eLS. .

Author Information

  1. Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France

Publication History

  1. Published Online: 23 SEP 2005


Multiple alignment is a powerful integrative tool that addresses a variety of biological problems, ranging from key functional residue detection to the evolution of a protein family. Traditionally, a multiple alignment was generally constructed as a series of pairwise alignments; however, the recent application of various new computational techniques to the multiple alignment problem has led to a number of interesting new developments.


  • progressive alignment;
  • iterative alignment;
  • hidden Markov model;
  • genetic algorithm;
  • objective function