Published Online: 23 SEP 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Thompson, J. and Poch, O. 2005. Multiple Alignment. eLS. .
- Published Online: 23 SEP 2005
Multiple alignment is a powerful integrative tool that addresses a variety of biological problems, ranging from key functional residue detection to the evolution of a protein family. Traditionally, a multiple alignment was generally constructed as a series of pairwise alignments; however, the recent application of various new computational techniques to the multiple alignment problem has led to a number of interesting new developments.
- progressive alignment;
- iterative alignment;
- hidden Markov model;
- genetic algorithm;
- objective function