Published Online: 23 SEP 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Hofmann, K. 2005. Profile Searching. eLS. .
- Published Online: 23 SEP 2005
A profile is a computational representation of sequence properties derived from a family of related proteins. Analogous to single sequences, profiles can be used for database searches using a dynamic programming algorithm. Because profiles allow position-specific scoring systems and gap parameters, profile searches offer a greatly increased sensitivity in detecting distant protein relationships.
- sequence analysis;
- evolutionary distance;
- statistical significance