Standard Article

RNA Secondary Structure Prediction

  1. Ivo L Hofacker

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005274



How to Cite

Hofacker, I. L. 2005. RNA Secondary Structure Prediction. eLS. .

Author Information

  1. University of Vienna, Vienna, Austria

Publication History

  1. Published Online: 23 SEP 2005


Functional RNA molecules tend to fold into evolutionarily well-conserved structures. On the level of secondary structures, such folding can be predicted by a variety of algorithms from the nucleotide sequence. The predicted structures can help to identify and compare functional RNAs.


  • RNA folding;
  • base pair;
  • energy minimization;
  • dynamic programming;
  • pair probability;
  • suboptimal structures