Telomeres: Protection and Maintenance
Published Online: 23 SEP 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
de Lange, T. 2005. Telomeres: Protection and Maintenance. eLS. .
- Published Online: 23 SEP 2005
Eukaryotic chromosomes terminate in telomeres, nucleoprotein complexes thought to mask chromosome ends from the machinery that detects and repairs damaged deoxyribonucleic acid (DNA). The maintenance of this protective telomeric cap requires a specialized mode of DNA synthesis, because chromosome duplication results in incomplete replication of DNA ends. Proteins associated with the telomeric DNA sequence at chromosome ends execute and regulate the maintenance and protection functions of telomeres.
- genome instability