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Transcriptional Regulation: Coordination

  1. Jean-Marc Egly,
  2. Cécile Rochette-Egly

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005288



How to Cite

Egly, J.-M. and Rochette-Egly, C. 2005. Transcriptional Regulation: Coordination. eLS. .

Author Information

  1. INSERM/CNRS/ULP, Illkirch, France

Publication History

  1. Published Online: 23 SEP 2005


In higher eukaryotes, gene expression is tightly coordinated at multiple stages with other events that orchestrate the life of the cell. Prompted by an initial signal, regulatory transcription factors are activated, assemble at specific enhancer sequences and trigger a cascade of reactions, resulting in an appropriately remodeled chromatin template, with functional transcription machinery on the promoter. Phosphorylation, acetylation and methylation orchestrate the interconnection of the different steps.


  • transcription;
  • initiation;
  • activators;
  • chromatin;
  • phosphorylation