Standard Article

Protein Targeting

  1. Dennis Brown

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005291



How to Cite

Brown, D. 2005. Protein Targeting. eLS. .

Author Information

  1. Massachusetts General Hospital, Boston, Massachusetts, USA

Publication History

  1. Published Online: 23 SEP 2005

This is not the most recent version of the article. View current version (16 JUN 2014)


Protein sorting is the process by which cellular proteins, both newly synthesized and recycling, are directed to the appropriate intracellular compartments in which they will perform their function. This process relies upon the targeting signals that are found within each protein. These specific signals direct the interaction of proteins with a multitude of accessory ‘targeting and trafficking’ factors to ensure the correct delivery of the proteins to their appropriate destinations within each cell.


  • sorting sequences;
  • cytoskeleton;
  • transport vesicles;
  • membrane fusion;
  • membrane domains