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Spliceosome

  1. Daniel A Pomeranz Krummel,
  2. Kiyoshi Nagai

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005323

eLS

eLS

How to Cite

Pomeranz Krummel, D. A. and Nagai, K. 2005. Spliceosome. eLS. .

Author Information

  1. Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

Publication History

  1. Published Online: 23 SEP 2005

This is not the most recent version of the article. View current version (15 NOV 2013)

Abstract

The removal of introns and the splicing together of the protein-coding regions or exons from precursor messenger RNA (pre-mRNA) transcripts is fundamental to the development and maintenance of human cells. The nuclear process of pre-mRNA splicing is a complex phenomenon catalyzed by the ‘spliceosome’, which comprises more than 100 hundred protein and RNA molecules that come on and off during its assembly and activity.

Keywords:

  • RNA splicing;
  • spliceosome;
  • pre-mRNA transcript;
  • snRNP;
  • introns