Standard Article

HAPPY Mapping

  1. Paul H Dear

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005362

eLS

eLS

How to Cite

Dear, P. H. 2005. HAPPY Mapping. eLS. .

Author Information

  1. Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

Publication History

  1. Published Online: 23 SEP 2005

Abstract

HAPPY mapping is a versatile in vitro method for making genome maps. Genomic deoxyribonucleic acid (DNA) is broken randomly and diluted to the point where samples contain only a few molecules. If two sequences (‘markers’) are then found together in the same sample, this implies that they are on the same DNA fragment and therefore adjacent in the genome.

Keywords:

  • genome mapping;
  • single-molecule analysis;
  • linkage analysis;
  • polymerase chain reaction