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HAPPY Mapping

  1. Paul H Dear

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005362



How to Cite

Dear, P. H. 2005. HAPPY Mapping. eLS. .

Author Information

  1. Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

Publication History

  1. Published Online: 23 SEP 2005


HAPPY mapping is a versatile in vitro method for making genome maps. Genomic deoxyribonucleic acid (DNA) is broken randomly and diluted to the point where samples contain only a few molecules. If two sequences (‘markers’) are then found together in the same sample, this implies that they are on the same DNA fragment and therefore adjacent in the genome.


  • genome mapping;
  • single-molecule analysis;
  • linkage analysis;
  • polymerase chain reaction