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Parametric and Nonparametric Linkage Analysis

  1. Joan E Bailey-Wilson

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005403



How to Cite

Bailey-Wilson, J. E. 2006. Parametric and Nonparametric Linkage Analysis. eLS. .

Author Information

  1. National Institutes of Health, Baltimore, Maryland, USA

Publication History

  1. Published Online: 27 JAN 2006


Parametric or model-based linkage analysis assumes that models describing both the trait and marker loci are known without error. Nonparametric, model-free or weakly parametric linkage methods make fewer assumptions about the trait model.


  • power;
  • type 1 error;
  • heterogeneity;
  • model-based;
  • bias