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Genetic Maps: Integration

  1. Andrew Collins

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005405

eLS

eLS

How to Cite

Collins, A. 2006. Genetic Maps: Integration. eLS. .

Author Information

  1. University of Southampton, Southampton, UK

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Genetic maps describe the order of polymorphisms along a chromosome; however, unlike physical maps, the map distances are related to recombination. The level of recombination varies with position along the chromosome and between the sexes. It is important to integrate genetic and physical or sequence-based maps to identify regions of elevated or reduced recombination. The presence of recombination hot and cold spots has a bearing on efforts to map disease genes and for the understanding of the biological properties of chromosome location.

Keywords:

  • linkage mapping;
  • recombination;
  • interference;
  • map integration