Standard Article


  1. Susan R Wilson

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005414



How to Cite

Wilson, S. R. 2006. Epistasis. eLS. .

Author Information

  1. Australian National University, Canberra, Australia

Publication History

  1. Published Online: 27 JAN 2006


Epistasis is the biological interaction between two or more genes to determine a phenotype. Until relatively recently, there has been confusion in its definition arising from many mathematical and other models not necessarily reflecting biological reality, and underestimation of both its importance in mapping results for complex disease and its potential role in the results of evolutionary genetics.


  • epistasis;
  • evolution;
  • population genetics;
  • complex disease;
  • association tests;
  • quantitative trait loci