Standard Article

Sample Size Requirements

  1. Michael Knapp

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005436



How to Cite

Knapp, M. 2006. Sample Size Requirements. eLS. .

Author Information

  1. University of Bonn, Bonn, Germany

Publication History

  1. Published Online: 27 JAN 2006


Sample size requirements in the context of linkage analysis between a trait and genetic markers refer to the calculation of the sample size required for a linkage study to guarantee a certain power of the study against an assumed inheritance model. The power against an assumed inheritance model is the probability of correctly declaring a linkage when in fact the assumed inheritance model is true and the trait and marker loci are linked.


  • power;
  • inheritance model;
  • parametric linkage analysis;
  • affected sibling pair test;
  • transmission/disequilibrium test