Allelic and Locus Heterogeneity
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Scriver, C. R. 2006. Allelic and Locus Heterogeneity. eLS.
- Published Online: 27 JAN 2006
‘Allelic heterogeneity’ implies that different alleles in the same gene can cause a similar variant phenotype. Genetic or ‘locus (nonallelic) heterogeneity’ implies that mutation in different genes may explain one variant phenotype. When simultaneous expression of mutations in different genes is necessary the phenotype is said to reflect digenic or oligogenic inheritance