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Retrotransposition and Human Disorders

  1. Eric M Ostertag,
  2. Haig H Kazazian Jr

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005492



How to Cite

Ostertag, E. M. and Kazazian, H. H. 2006. Retrotransposition and Human Disorders. eLS. .

Author Information

  1. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 27 JAN 2006

This is not the most recent version of the article. View current version (15 SEP 2011)


  1. References
  2. Further Reading
  3. Web Links

Further Reading

  1. References
  2. Further Reading
  3. Web Links
  • Deragon JM and Capy P (2000) Impact of transposable elements on the human genome. Annals of Medicine 32: 264273.
  • Furano AV (2000) The biological properties and evolutionary dynamics of mammalian LINE-1 retrotransposons. Progress in Nucleic Acid Research and Molecular Biology 64: 255294.
  • Kazazian Jr HH (2000) L1 retrotransposons shape the mammalian genome. Science 289: 11521153.
  • Kazazian Jr HH and Moran JV (1998) The impact of L1 retrotransposons on the human genome. Nature Genetics 19: 1924.
  • Luan DD and Eickbush TH (1996) Downstream 28S gene sequences on the RNA template affect the choice of primer and the accuracy of initiation by the R2 reverse transcriptase. Molecular and Cellular Biology 16: 47264734.
  • Makalowski W, Mitchell GA and Labuda D (1994) Alu sequences in the coding regions of mRNA: a source of protein variability. Trends in Genetics 10: 188193.
  • Maraia RJ (1995) Alu elements as a source of genomic variation: deleterious effects and evolutionary novelties. In: Maraia RJ (ed.) The Impact of Short Interspersed Elements (SINEs) on the Host Genome, pp. 124. Georgetown, TX: Landes Bioscience.
  • Miki Y (1998) Retrotransposal integration of mobile genetic elements in human diseases. Journal of Human Genetics 43: 7784.
  • Moran JV and Gilbert N (2001) Mammalian LINE-1 retrotransposons and related elements.In: Craig N (ed.) Mobile DNA, pp. 836869. Washington, DC: American Society for Microbiology.