Standard Article
Protein Aggregation and Human Disorders
Published Online: 27 JAN 2006
DOI: 10.1038/npg.els.0005496
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
Book Title
eLS
Additional Information
How to Cite
Moir, R. D. and Tanzi, R. E. 2006. Protein Aggregation and Human Disorders. eLS. .
Publication History
- Published Online: 27 JAN 2006
- Abstract
- Article
- References
Abstract
The deposition of insoluble proteinaceous material is a distinct pathological process associated with a broad range of disparate diseases. Modulating the self-aggregation of the proteins that form these deposits has emerged as a major therapeutic strategy for disease treatment.
Keywords:
- aggregation;
- amyloid;
- prion;
- fibrils;
- polyglutamine repeat
