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Protein Aggregation and Human Disorders

  1. Robert D Moir,
  2. Rudolph E Tanzi

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005496

eLS

eLS

How to Cite

Moir, R. D. and Tanzi, R. E. 2006. Protein Aggregation and Human Disorders. eLS. .

Author Information

  1. Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA

Publication History

  1. Published Online: 27 JAN 2006

Abstract

The deposition of insoluble proteinaceous material is a distinct pathological process associated with a broad range of disparate diseases. Modulating the self-aggregation of the proteins that form these deposits has emerged as a major therapeutic strategy for disease treatment.

Keywords:

  • aggregation;
  • amyloid;
  • prion;
  • fibrils;
  • polyglutamine repeat