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Genomic and Chromosomal Instability

  1. Haiwei H Guo,
  2. John F Davidson,
  3. Lawrence A Loeb

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005499



How to Cite

Guo, H. H., Davidson, J. F. and Loeb, L. A. 2006. Genomic and Chromosomal Instability. eLS. .

Author Information

  1. University of Washington School of Medicine, Seattle, WA, USA

Publication History

  1. Published Online: 27 JAN 2006


The multiplicity of mutations found in human cancers reflects the consequences of breakdown in genome maintenance and helps to provide insight into the origins of malignancy.


  • genetic instability;
  • DNA damage;
  • DNA repair;
  • mutation;
  • cancer