Standard Article

Nonsense-mediated mRNA Decay

  1. Joshua T Mendell,
  2. Harry C Dietz

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005501



How to Cite

Mendell, J. T. and Dietz, H. C. 2006. Nonsense-mediated mRNA Decay. eLS. .

Author Information

  1. Johns Hopkins University School of Medicine and Howard Hughes Medical Institute, Baltimore, Maryland, USA

Publication History

  1. Published Online: 27 JAN 2006


Nonsense-mediated mRNA decay is the recognition and selective decay of transcripts containing premature termination codons, which occurs in all studied eukaryotic organisms.


  • nonsense-mediated mRNA decay;
  • nonsense mutation;
  • premature termination codon;
  • mRNA stability;
  • mRNA surveillance