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3′ UTR Mutations and Human Disorders

  1. Béatrice Conne,
  2. André Stutz,
  3. Jean-Dominique Vassalli

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005502



How to Cite

Conne, B., Stutz, A. and Vassalli, J.-D. 2006. 3′ UTR Mutations and Human Disorders. eLS. .

Author Information

  1. University of Geneva, Geneva, Switzerland

Publication History

  1. Published Online: 27 JAN 2006


The 3′ untranslated region (3′ UTR) of a number of messenger ribonucleic acids (mRNAs) is involved in the regulation of the processing, localization, translation or degradation of the transcript. Perturbations in such 3′ UTR-mediated functions are implicated in a variety of human diseases.


  • mRNA processing;
  • mRNA translation;
  • mRNA degradation;
  • 3′ untranslated region;
  • posttranscriptional control;
  • human diseases;
  • mRNA stability;
  • trans-acting factors;
  • cis-acting determinants