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G-protein-mediated Signal Transduction and Human Disorders

  1. Allen M Spiegel

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005505

eLS

eLS

How to Cite

Spiegel, A. M. 2006. G-protein-mediated Signal Transduction and Human Disorders. eLS. .

Author Information

  1. National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Heterotrimeric G proteins couple to seven-transmembrane receptors, producing diverse signals to effectors that generate intracellular signals. Loss- and gain-of-function mutations in genes encoding G-protein-coupled receptors and the α subunit of heterotrimeric G proteins have been increasingly recognized as causes of human disease.

Keywords:

  • signal transduction;
  • receptors;
  • G proteins;
  • hormone resistance;
  • second messengers