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Fusion Proteins and Diseases

  1. Vaskar Saha,
  2. Louise Kathleen Jones

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005543

eLS

eLS

How to Cite

Saha, V. and Jones, L. K. 2006. Fusion Proteins and Diseases. eLS. .

Author Information

  1. Institute of Cancer Research, London, UK

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Fusion proteins occur as a result of chromosomal translocations in cancerous cells. The proteins targeted are either transcription factors or tyrosine kinases. The fusion proteins are associated with developmental malignancies and thyroid carcinomas.

Keywords:

  • chromosomal translocations;
  • transcription factors;
  • tyrosine kinase;
  • leukemia;
  • sarcoma;
  • thyroid carcinoma;
  • chromatin;
  • cell-cycle signaling pathways