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Zebrafish as a Model for Human Diseases

  1. Paula Goodman Fraenkel1,
  2. Leonard I Zon2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005580

eLS

eLS

How to Cite

Fraenkel, P. G. and Zon, L. I. 2006. Zebrafish as a Model for Human Diseases. eLS. .

Author Information

  1. 1

    Children's Hospital and Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

  2. 2

    Howard Hughes Medical Institute, Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Zebrafish (Danio rerio) are small freshwater fish, the only vertebrate model in which a large-scale mutagenesis strategy has been undertaken as an approach to the study of the development of blood and vital organs. The development of techniques for gene mapping in zebra fish and the anticipated completion of the zebra fish genome sequencing project in 2002 will enhance the use of zebra fish as models for human diseases.

Keywords:

  • zebra fish;
  • genetic screens;
  • development;
  • hematopoiesis;
  • human diseases