Mammalian Artificial Chromosomes (MACs)
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Farr, C. J. and Spence, J. M. 2006. Mammalian Artificial Chromosomes (MACs). eLS. .
- Published Online: 27 JAN 2006
By analogy with yeast artificial chromosomes, a mammalian artificial chromosome (MAC) would be a molecule of defined structure comprising combinations of various cloned or synthesized chromosomal elements that had been individually manipulated, tested and optimized as part of a controlled construction process. De novo human chromosomes have been produced through cell-mediated assembly processes and these, together with minichromosomes generated by manipulating existing chromosomes, are providing the basis for developing the first MAC-based vectors for use in vertebrate cells.