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Fusion Proteins as Research Tools

  1. Josephine C Dorsman

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005685



How to Cite

Dorsman, J. C. 2006. Fusion Proteins as Research Tools. eLS. .

Author Information

  1. University of Leiden, Leiden, The Netherlands

Publication History

  1. Published Online: 27 JAN 2006


Fusion proteins encompass a protein or small peptide moiety which is used as a tag, fused to another protein of interest. Fusion proteins are used in biochemical and in genetic (high-throughput) applications and are especially suited to study protein–protein interactions, even on a genome-wide scale, and for the generation of antibodies.


  • fusion proteins;
  • GST system;
  • single-step purification;
  • yeast two-hybrid;
  • protein–protein interaction