Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Villar, A. J. and Epstein, C. J. 2006. Down Syndrome. eLS. .
- Published Online: 27 JAN 2006
This is not the most recent version of the article. View current version (17 OCT 2011)
Down syndrome, first described by Langdon Down in 1866, is caused by an extra copy of chromosome 21. It is the most commonly recognized genetic cause of mental retardation and is characterized by a number of dysmorphic features and congenital malformations.
- mental retardation;
- chromosome 21;
- Alzheimer disease;
- congenital heart disease;
- mouse models