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Protein Isoforms and Isozymes

  1. Peter William Gunning

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005717



How to Cite

Gunning, P. W. 2006. Protein Isoforms and Isozymes. eLS. .

Author Information

  1. The Children's Hospital at Westmead, Sydney, Australia

Publication History

  1. Published Online: 27 JAN 2006


Isoforms are highly related gene products that perform essentially the same biological function. Isozymes are isoforms of an enzyme. Isoforms can differ in their biological activity, regulatory properties, temporal and spatial expression, intracellular location or any combination thereof. Isoforms are almost always either the products of one gene or of multiple genes that evolved from a single ancestor gene.


  • evolution;
  • alternative splicing;
  • sorting;
  • gene duplication;
  • gene regulation