Standard Article

Protein Degradation and Turnover

  1. Tomo Saric1,
  2. Alfred L Goldberg2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005722



How to Cite

Saric, T. and Goldberg, A. L. 2006. Protein Degradation and Turnover. eLS. .

Author Information

  1. 1

    ATABIS GmbH, Cologne, Germany

  2. 2

    Harvard Medical School, Boston, Massachusetts, USA

Publication History

  1. Published Online: 27 JAN 2006


The protein constituents of an organism and its cells are continuously being synthesized and degraded (turned over). Protein degradation is essential for recycling of amino acids, removal of damaged or misfolded proteins and controlling a variety of fundamental biological processes.


  • lysosome;
  • ubiquitin;
  • proteasome;
  • protease;
  • ATPase;
  • disease