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Synchronous and Asynchronous Replication

  1. Sara Selig

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005771



How to Cite

Selig, S. 2006. Synchronous and Asynchronous Replication. eLS. .

Author Information

  1. Technion, Haifa, Israel

Publication History

  1. Published Online: 27 JAN 2006


Replication of nuclear DNA in animal cells is carried out according to a temporal program that is conserved from one cell division to the next. The order of replication of genomic regions can be determined by various methods. In most genomic regions both allelic copies replicate synchronously, with the exception of the X chromosomes in female mammals, regions containing imprinted genes or genes with one randomly inactivated allele.


  • replication timing;
  • replication bands;
  • FISH replication assay;
  • asynchronous replication