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Mitosis: Chromosome Segregation and Stability

  1. Loren Michel,
  2. Robert Benezra

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005774

eLS

eLS

How to Cite

Michel, L. and Benezra, R. 2006. Mitosis: Chromosome Segregation and Stability. eLS. .

Author Information

  1. Memorial Sloan-Kettering Cancer Center, New York, USA

Publication History

  1. Published Online: 27 JAN 2006

This is not the most recent version of the article. View current version (16 MAR 2015)

Abstract

Mammalian cells are charged with the task of evenly distributing 46 chromosomes to each of two daughter cells during every mitotic cell cycle. Abnormal function of any one of the numerous genes involved in this process can result in the aberrant transmission of chromosomes from the parental cell to its progeny.

Keywords:

  • aneuploidy;
  • centrosome;
  • checkpoint;
  • chromosome;
  • mitosis