Standard Article

Microdeletions and Microduplications: Mechanism

  1. Bernice E Morrow

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005789

eLS

eLS

How to Cite

Morrow, B. E. 2006. Microdeletions and Microduplications: Mechanism. eLS. .

Author Information

  1. Albert Einstein College of Medicine, Bronx, New York, USA

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Microdeletions and microduplications in the genome are caused by chromosome misalignment between blocks of region-specific low copy repeats and result in genomic disorders.

Keywords:

  • chromosome rearrangements;
  • genomic disorders;
  • 22q11;
  • low copy repeats;
  • congenital anomaly disorders;
  • homologous recombination