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Major Histocompatibility Complex (MHC) Genes

  1. Jerzy K Kulski1,
  2. Hidetoshi Inoko2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005900



How to Cite

Kulski, J. K. and Inoko, H. 2006. Major Histocompatibility Complex (MHC) Genes. eLS. .

Author Information

  1. 1

    Tokai University School of MedicineKanagawa, Japan and CBBC Information Technology, Murdoch University, Murdoch, Australia

  2. 2

    Tokai University School of Medicine, Kanagawa, Japan

Publication History

  1. Published Online: 27 JAN 2006


MHC genes are located within the human major histocompatibility complex (MHC) and code for different members of the class I and the class II human leukocyte antigen (HLA) families. The HLA class I and class II molecules are polymorphic cell membrane-bound glycoproteins and, as part of the immunosurveillance system, they regulate the immune response by presenting fragmented proteins (peptides) to circulating cytotoxic and helper T lymphocytes respectively.


  • MHC;
  • HLA;
  • class I;
  • class II;
  • duplication;
  • polymorphism