Standard Article


  1. Detlef Doenecke,
  2. Werner Albig

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005908



How to Cite

Doenecke, D. and Albig, W. 2006. Histones. eLS. .

Author Information

  1. Georg-August-Universität Göttingen, Göttingen, Germany

Publication History

  1. Published Online: 27 JAN 2006


Histones, the major protein constituents of the eukaryotic chromosomes, are small proteins that are enriched in basic amino acids and highly conserved in evolution. They are classified either on the basis of their content of basic amino acids as very lysine rich (H1), moderately lysine rich (H2A and H2B) and arginine rich (H3 and H4), or in respect to their position in the nucleosome as linker or core histones.


  • histones;
  • replacement histones;
  • histone genes;
  • gene cluster;
  • pseudogenes