Standard Article


  1. Stephen C-T Lam1,
  2. Joseph C Loftus2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005910



How to Cite

Lam, S. C.-T. and Loftus, J. C. 2006. Integrins. eLS. .

Author Information

  1. 1

    University of Illinois at Chicago, Chicago, Illinois, USA

  2. 2

    Mayo Clinic Scottsdale, Scottsdale, Arizona, USA

Publication History

  1. Published Online: 27 JAN 2006


Integrins are transmembrane αβ heterodimeric receptor complexes involved in diverse pathophysiological processes by mediating cell adhesion and migration. Integrin–ligand interaction and postligand binding functions of integrins are regulated by intracellular signaling mechanisms.


  • adhesion;
  • migration;
  • extracellular matrix;
  • cytoskeleton;
  • signaling