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Severe Combined Immune Deficiency (SCID): Genetics

  1. A Fischer

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005941



How to Cite

Fischer, A. 2006. Severe Combined Immune Deficiency (SCID): Genetics. eLS. .

Author Information

  1. Hôpital Necker, Paris, France

Publication History

  1. Published Online: 27 JAN 2006

This is not the most recent version of the article. View current version (15 NOV 2011)


Severe combined immunodeficiency consists of an array of genetically determined blocks in T lymphocyte development. Characterization of genetic defects contributes to a better understanding of lymphocyte differentiation pathways.


  • Severe combined immunodeficiencies;
  • hematopoietic stem cells;
  • T lymphocytes;
  • B lymphocytes;
  • NK lymphocytes;
  • lymphocyte differentiation