Standard Article

Microarrays in Toxicological Research

  1. William D Pennie

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005950

eLS

eLS

How to Cite

Pennie, W. D. 2006. Microarrays in Toxicological Research. eLS. .

Author Information

  1. Pfizer Drug Safety Evaluation, Groton, Connecticut, USA

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Toxicologists are increasingly applying oligonucleotide and complementary DNA microarrays in an attempt to understand adverse chemical reactions that occur during gene transcription. When applied in concert with the more established approaches of biochemical toxicology, pathology and so on, the appropriate use of these microarrays is improving our fundamental knowledge of mechanisms of toxicity and will have profound impact on safety assessment processes in the discovery and development of new pharmaceuticals.

Keywords:

  • toxicology;
  • microarray;
  • gene expression;
  • bioinformatics;
  • database transcription, drug development