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DNA Coiling and Unwinding

  1. Yannick Hugodot,
  2. Michel Duguet

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005967



How to Cite

Hugodot, Y. and Duguet, M. 2006. DNA Coiling and Unwinding. eLS. .

Author Information

  1. Université Paris-Sud, Orsay, France

Publication History

  1. Published Online: 27 JAN 2006


The double-helical structure of DNA and its higher orders of coiling are tightly controlled by two classes of enzyme, helicases and topoisomerases. These are part of large protein complexes that control the main DNA transactions within the cell. In humans, defects in these enzymes may result in various diseases.


  • DNA supercoiling;
  • topoisomerase;
  • helicase;
  • unwinding