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Promoter Haplotypes and Gene Expression

  1. Paulus HLJ Joosten

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005968



How to Cite

Joosten, P. H. 2006. Promoter Haplotypes and Gene Expression. eLS. .

Author Information

  1. University of Nijmegen, Nijmegen, The Netherlands

Publication History

  1. Published Online: 27 JAN 2006


There is an estimated 0.1% difference between any two human genomes. The differences occur predominantly outside protein-coding regions and result in, for example, different promoter haplotypes. The generation of a high-resolution human genomic sequence will allow us to investigate the role of genetic variance in common diseases, which tend to be multifactorial with a non-Mendelian inheritance.


  • polymorphism;
  • genetics;
  • disease;
  • haplotype;
  • transcription