Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Pikaard, C. S. 2006. Nucleolar Dominance. eLS. .
- Published Online: 27 JAN 2006
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Nucleolar dominance is an epigenetic phenomenon in plant and animal hybrids that describes the failure to form nucleoli, the sites of ribosome synthesis, on chromosomes inherited from one parent. The molecular basis for nucleolar dominance is the reversible silencing of ribosomal RNA genes transcribed by RNA polymerase I. These genes are clustered at loci spanning millions of base pairs, making nucleolar dominance one of the most extensive known chromosomal-silencing phenomena.
- gene silencing;
- epigenetic phenomena;
- ribosomal RNA;
- RNA polymerase I;
- nucleolus organizer