Cre–lox-Inducible Gene Targeting
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Sauer, B. 2006. Cre–lox-Inducible Gene Targeting. eLS. .
- Published Online: 27 JAN 2006
Cre is a site-specific DNA recombinase that is useful for either targeted excision or activation of a desired gene in the genome in a temporally and spatially controlled manner. Cre-based recombination strategies also permit the design of precise chromosome translocations, deletions and duplications, which facilitate the genetic manipulation of the eukaryotic genome.
- transgenic mice;
- chromosome engineering;
- DNA recombinase;
- conditional mutation;
- embryonic stem cells