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Gene Targeting by Homologous Recombination

  1. John H Wilson1,
  2. Karen M Vasquez2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005988



How to Cite

Wilson, J. H. and Vasquez, K. M. 2006. Gene Targeting by Homologous Recombination. eLS. .

Author Information

  1. 1

    Baylor College of Medicine, Houston, Texas, USA

  2. 2

    University of Texas, M. D. Anderson Cancer Center, Science Park – Research Division, Smithville, Texas, USA

Publication History

  1. Published Online: 27 JAN 2006

This is not the most recent version of the article. View current version (15 APR 2014)


Homologous recombination involves the exchange of DNA molecules in regions of homology by a crossover event. Homologous recombination provides a mechanism for targeting defined modifications into genes of interest.


  • homologous recombination;
  • gene targeting;
  • mouse disease models;
  • genome modification;
  • triplex technology