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Skeletogenesis: Genetics

  1. Pancras CW Hogendoorn,
  2. Judith VMG Bovée,
  3. Marcel Karperien,
  4. Anne-Marie Cleton-Jansen

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0005996



How to Cite

Hogendoorn, P. C., Bovée, J. V., Karperien, M. and Cleton-Jansen, A.-M. 2006. Skeletogenesis: Genetics. eLS. .

Author Information

  1. Leiden University Medical Centre, Leiden, The Netherlands

Publication History

  1. Published Online: 27 JAN 2006

This is not the most recent version of the article. View current version (8 DEC 2013)


Skeletogenesis is a tightly regulated process during fetal, postnatal and pubertal growth, finely orchestrated by transcription factors and consecutive signaling pathways and controlled by delicate feedback loops. There is an increasing awareness of the role of these processes during tumorigenesis of primary bone tumors.


  • bone;
  • bone neoplasm;
  • growth regulation;
  • chondrosarcoma;
  • osteosarcoma;
  • bone formation;
  • osteoblast;
  • chondrocyte;
  • osteoclast