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Tumor Suppressor Genes

  1. Martin L Hooper

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006005

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Hooper, M. L. 2006. Tumor Suppressor Genes. eLS. .

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  1. University of Edinburgh, Edinburgh, UK

Publication History

  1. Published Online: 27 JAN 2006
Table 1. Some tumor suppressor genes and their associated familial cancer syndromes
GeneSyndromeAffected tissues or organs
RB1Familial retinoblastomaRetina, bone
Wilms tumor 1 (WT1)Syndromes associated with Wilms' tumor, e.g. WAGR syndrome, Denys–Drash syndromeKidney
p53 (TP53)Li–Fraumeni syndromeMany, most commonly breast and brain
neurofibromin 1 (NF1)Neurofibromatosis type 1Peripheral nervous system, skin, iris
neurofibromin 2 (NF2)Neurofibromatosis type 2Central nervous system
breast cancer 1, early onset (BRCA1)Breast cancerBreast
breast cancer 2, early onset (BRCA2)Breast cancerBreast
adenomatous polyposis coli (APC)Familial adenomatous polyposisColon
MSH2HNPCC (hereditary nonpolyposis colorectal cancer)Colon
MSH6HNPCCColon
MLH1HNPCCColon
PMS2HNPCCColon
DPC4 (MADH4)Juvenile polyposisGastrointestinal tract
VHLvon Hippel–Lindau syndromeCentral nervous system, adrenal, kidney, pancreas
E-CAD (CDH18)Familial gastric cancerStomach
p16 (CDKN2A)Familial melanomaSkin