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Nuclear Receptors and Disease

  1. James Daniel Love

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006024

eLS

eLS

How to Cite

Love, J. D. 2006. Nuclear Receptors and Disease. eLS. .

Author Information

  1. Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Nuclear receptors are ligand-modulated transcription factors that act in the nucleus to regulate target gene transcription through interaction with cofactor proteins. Owing to their roles in many diverse cellular processes, nuclear receptors are important therapeutic targets and aberrant receptor action results in significant human disease.

Keywords:

  • transcription factors;
  • corepressor;
  • ligand;
  • coactivator;
  • repression