Standard Article

You have free access to this content

Cell Cycle Checkpoint Genes and Cancer

  1. Jens Oliver Funk1,2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006046

eLS

eLS

How to Cite

Funk, J. O. 2006. Cell Cycle Checkpoint Genes and Cancer. eLS. .

Author Information

  1. 1

    University of Erlangen-Nuremberg, Erlangen, Germany

  2. 2

    Oncology Research Darmstadt, Global Preclinical R&D, Merck KGaA, Darmstadt, Germany

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Several genes have been identified that control different ‘checkpoints’ in the cell division cycle. Some of these may have clinical significance, in the diagnosis and possible treatment of some cancers.

Keywords:

  • cyclin-dependent kinase;
  • tumor suppressor;
  • p53;
  • CDK inhibitor, oncogene, DNA damage