Standard Article

Gene Amplification and Cancer

  1. Kazuhiko Uchida

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006047

eLS

eLS

How to Cite

Uchida, K. 2006. Gene Amplification and Cancer. eLS. .

Author Information

  1. University of Tsukuba, Tsukuba, Ibaraki, Japan

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Several types of alterations in the deoxyribonucleic acid (DNA) of somatic cells can induce phenotypic changes that lead to cancer, and gene amplification is the most frequently observed type of genetic change associated with cancer. The mechanisms of gene amplification are not well understood, but better understanding of the role played by gene amplification in cancer may lead to new cancer biomarkers and improved prognostic and diagnostic indicators of cancer progression.

Keywords:

  • adaptive amplification;
  • comparative genomic hybridization;
  • genetic instability;
  • oncogene;
  • aneuploidy