Gene Amplification and Cancer
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Uchida, K. 2006. Gene Amplification and Cancer. eLS. .
- Published Online: 27 JAN 2006
Several types of alterations in the deoxyribonucleic acid (DNA) of somatic cells can induce phenotypic changes that lead to cancer, and gene amplification is the most frequently observed type of genetic change associated with cancer. The mechanisms of gene amplification are not well understood, but better understanding of the role played by gene amplification in cancer may lead to new cancer biomarkers and improved prognostic and diagnostic indicators of cancer progression.
- adaptive amplification;
- comparative genomic hybridization;
- genetic instability;