Caretakers and Gatekeepers
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Russo, A., Migliavacca, M., Zanna, I., Macaluso, M., Gebbia, N. and Bazan, V. 2006. Caretakers and Gatekeepers. eLS. .
- Published Online: 27 JAN 2006
It has now been generally accepted that the genes responsible for familial cancer syndromes can be divided into two categories, known as caretakers and gatekeepers. Caretakers are genes that control the maintenance of the genetic information integrity in each cell while gatekeepers are those genes which directly regulate tumor growth, codifying for proteins which either stimulate or inhibit proliferation, differentiation or apoptosis.
- gatekeeper genes;
- caretaker genes;
- tumor suppressor genes;
- cell cycle;
- hereditary syndromes